A study on functional similarity between dengue non structural protein 1 and platelet integrin/adhesin protein, CD61.

BACKGROUND Dengue infection is a major public health problem. The mechanisms underlying severe bleeding in dengue DHF are not completely understood. It was proposed that the dengue virus nonstructural-1 protein (DNS1) generated antibodies to common epitopes on human blood clotting and integrin/adhesin proteins on the platelet. The proof on the functional correlation between DNS1 and platelet integrin/adhesin proteins is needed. METHODS Here, the author used a new gene ontology technology to predict the molecular function and biological process of DNS1 and platelet integrin/adhesin protein, CD61. RESULT According to this study, the author can identify no function and biological process of DNS1. Also, there is no existence of functional similarity between DNS1 and CD61. CONCLUSION The hypothesis on role of molecular mimicry between DNS1 and CD61 is not supported in this study.